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AERx Inhalation Technology Platform
 Liposomal
Formulations
Intellectual Property
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Liposomal Formulations for Inhalation
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“Nanopackaging” of drugs
• Sustained release within lung
• Ideal for AERx platform
• Applicable to multiple products
Aradigm’s
liposome formulations are nano-size liquid vesicles made out
of lipids that encapsulate drugs. When the drug in these vesicles
is deposited in the respiratory tract, it is slowly released,
with the view to provide sustained delivery of the drug at the
site of action and only minimum concentration of the drug in
the rest of the body. Purposeful formulations of liposomes can
also achieve preferential targeting of drugs to certain cell
types, maximizing the efficacy of and minimizing the toxicity
of the drug.
Scientific Publications
Deshpande,
D.., J.D. Blanchard, S. Srinivasan, D. Fairbanks, J. Fuijimoto,
T. Sawa, J. Weiner-Kronish, H. Schreier, and I. Gonda. Aerosolization
of lipoplexes using AERx Pulmonary Delivery System. AAPS
PharmSci. 4(3): article 13, 2002 (www.aapspharmsci.org).
Blanchard, J.D. Pulmonary drug delivery as a first response
to bioterrorism. In: Dalby, R.N, P.R. Byron, J. Peart, J.D.
Suman, and S.J. Farr, eds., Respiratory Drug Delivery X,
River Grove, IL: Davis Healthcare International, 2006, 73-82.
Educational Links
For more information on inhalation therapy and aerosol delivery,
refer to the following resources:
ISAM
Aerosol Society
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