Aradigm’s
scientists have published extensively on aerosol formulation and
pulmonary drug delivery. Excerpts from their bibliographies are
cited below. Abstracts can be viewed by clicking on each of the
links.
AERx® Technology
Gonda, I. et al.: “Inhalation Delivery Systems with
Compliance and Disease Management Capabilities” Journal of
Controlled Release 1998; 53:269-274.
Schuster, J. et al.: “The AERx Aerosol Delivery System”
Pharmaceutical Research 1997;14(3):354-357.
Farr, S.J. et al. “AERx – Development of a Novel Liquid
Aerosol Delivery System” Respiratory Drug Delivery V. Dalby,
R.N. et al. (eds.) Interpharm Press Inc., Buffalo Grove, Illinois.
1996, pp. 175-184.
Small Molecules
Okumu, F.W. et al.: “Evaluation of the AERx Pulmonary
Delivery System for Systemic Delivery of a Poorly Soluble Selective
D-1 Agonist, ABT-431” Pharmaceutical Research 2002;19(7):1009-1012.
Derschwitz M. et al.: “Pharmacokinetics and Pharmacodynamics
of Inhaled Versus Intravenous Morphine in Healthy Volunteers”
Anesthesiology 2000;93(3):619-628.
Chan, H.K. et al.: “Deposition of Aqueous Aerosol of Technetium-99m
Diethylene Triamine Penta-acetic Acid Generated and Delivered by
a Novel System (AERx) in Healthy Subjects” European Journal
of Nuclear Medicine 1999; 26(4): 320-37.
Mather L.E. et al.: “Pulmonary Administration of Aerosolized
Fentanyl: Pharmacokinetic Analysis of Systemic Delivery” British
Journal of Clinical Pharmacology 1998; 46:37-43.
Davison, S., J. Thipphawong, J. Blanchard, K. Liu, R. Morishige,
I. Gonda, J. Okikawa, J. Adams, A.M. Evan, B. Otulana, and S.R.
Davis. Pharmacokinetics and acute safety of inhaled testosterone
in postmenopausal women. J. Clin. Pharmacol. 45: 177-184,
2005.
Peptide and Protein Delivery
Thipphawong, J. et al.: “Pulmonary Insulin Administration
Using the AERx® Insulin Diabetes System” Diabetes Technology
& Therapeutics 2002; 4(4): 499-504.
Sangwan, S. et al.: “Aerosolized Protein Delivery in Asthma:
Gamma Camera Analysis of Regional Deposition and Perfusion”
Journal of Aerosol Medicine. 2001;14(2):185-195.
Mudumba S. et al.: “Delivery of rhDNase Using the AERx®
Pulmonary Delivery System” Respiratory Drug Delivery VII.
Dalby R.N. et al (eds) Serentec Press, Raliegh, NC. 2000. pp. 329-332.
Brunner, G.A. et al.: “Dose-Response Relation of Liquid Aerosol
Inhaled Insulin in Type I Diabetic Patients” Diabetologia
1991; 44:305-308.
Geller, D. et al.: "Bolus Inhalation of rhDNase with the AERx
System in Subjects with Cystic Fibrosis" Journal of Aerosol
Medicine 2003. 16(2): 175-182.
Gene Therapy
Desphande D. et al. “Aerosolization of Lipoplexes
Using AERx® Pulmonary Delivery System” AAPS Pharmaceutical
Sciences 2002. 4(3): 1-10.
Deshpande, D.S., J. D. Blanchard, J. Schuster, D. Fairbanks, C.
Hobbs, , R. Beihn, C. Densmore, S. Farr, and I. Gonda. Gamma scintigraphic
evaluation of a miniaturized AERxÒ Pulmonary Delivery System
for aerosol delivery to anesthetized animals using a positive pressure
ventilation system. J. Aerosol Med. 18: 34-4, 2005.
Educational Links
For more information on diabetes, access the following resources:
American Association
for Drug Research
Aerosol
Society
The International
Society for Aerosols in Medicine
Controlled
Release Society
Respiratory
Drug Delivery

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