Aradigm’s scientists have published extensively on aerosol formulation and pulmonary drug delivery. Excerpts from their bibliographies are cited below. Abstracts can be viewed by clicking on each of the links.

AERx Technology
Gonda, I. et al.: “Inhalation Delivery Systems with Compliance and Disease Management Capabilities” Journal of Controlled Release 1998; 53:269-274.

Schuster, J. et al.: “The AERx Aerosol Delivery System” Pharmaceutical Research 1997;14(3):354-357.

Farr, S.J. et al. “AERx – Development of a Novel Liquid Aerosol Delivery System” Respiratory Drug Delivery V. Dalby, R.N. et al. (eds.) Interpharm Press Inc., Buffalo Grove, Illinois. 1996, pp. 175-184.

Small Molecules
Okumu, F.W. et al.: “Evaluation of the AERx Pulmonary Delivery System for Systemic Delivery of a Poorly Soluble Selective D-1 Agonist, ABT-431” Pharmaceutical Research 2002;19(7):1009-1012.

Derschwitz M. et al.: “Pharmacokinetics and Pharmacodynamics of Inhaled Versus Intravenous Morphine in Healthy Volunteers” Anesthesiology 2000;93(3):619-628.

Chan, H.K. et al.: “Deposition of Aqueous Aerosol of Technetium-99m Diethylene Triamine Penta-acetic Acid Generated and Delivered by a Novel System (AERx) in Healthy Subjects” European Journal of Nuclear Medicine 1999; 26(4): 320-37.

Mather L.E. et al.: “Pulmonary Administration of Aerosolized Fentanyl: Pharmacokinetic Analysis of Systemic Delivery” British Journal of Clinical Pharmacology 1998; 46:37-43.

Davison, S., J. Thipphawong, J. Blanchard, K. Liu, R. Morishige, I. Gonda, J. Okikawa, J. Adams, A.M. Evan, B. Otulana, and S.R. Davis. Pharmacokinetics and acute safety of inhaled testosterone in postmenopausal women. J. Clin. Pharmacol. 45: 177-184, 2005.

Peptide and Protein Delivery
Thipphawong, J. et al.: “Pulmonary Insulin Administration Using the AERx® Insulin Diabetes System” Diabetes Technology & Therapeutics 2002; 4(4): 499-504.

Sangwan, S. et al.: “Aerosolized Protein Delivery in Asthma: Gamma Camera Analysis of Regional Deposition and Perfusion” Journal of Aerosol Medicine. 2001;14(2):185-195.

Mudumba S. et al.: “Delivery of rhDNase Using the AERx® Pulmonary Delivery System” Respiratory Drug Delivery VII. Dalby R.N. et al (eds) Serentec Press, Raliegh, NC. 2000. pp. 329-332.

Brunner, G.A. et al.: “Dose-Response Relation of Liquid Aerosol Inhaled Insulin in Type I Diabetic Patients” Diabetologia 1991; 44:305-308.

Geller, D. et al.: "Bolus Inhalation of rhDNase with the AERx System in Subjects with Cystic Fibrosis" Journal of Aerosol Medicine 2003. 16(2): 175-182.

Gene Therapy
Desphande D. et al. “Aerosolization of Lipoplexes Using AERx® Pulmonary Delivery System” AAPS Pharmaceutical Sciences 2002. 4(3): 1-10.

Deshpande, D.S., J. D. Blanchard, J. Schuster, D. Fairbanks, C. Hobbs, , R. Beihn, C. Densmore, S. Farr, and I. Gonda. Gamma scintigraphic evaluation of a miniaturized AERxÒ Pulmonary Delivery System for aerosol delivery to anesthetized animals using a positive pressure ventilation system. J. Aerosol Med. 18: 34-4, 2005.

Educational Links
For more information on diabetes, access the following resources:
American Association for Drug Research
Aerosol Society
The International Society for Aerosols in Medicine
Controlled Release Society
Respiratory Drug Delivery