Aradigm’s scientists have published extensively on aerosol formulation and pulmonary drug delivery. Excerpts from their bibliographies are cited below. Abstracts can be viewed by clicking on each of the links.

AERx® Technology
Gonda, I. et al.: “Inhalation Delivery Systems with Compliance and Disease Management Capabilities” Journal of Controlled Release 1998; 53:269-274.

Schuster, J. et al.: “The AERx Aerosol Delivery System” Pharmaceutical Research 1997;14(3):354-357.

Farr, S.J. et al. “AERx – Development of a Novel Liquid Aerosol Delivery System” Respiratory Drug Delivery V. Dalby, R.N. et al. (eds.) Interpharm Press Inc., Buffalo Grove, Illinois. 1996, pp. 175-184.

Small Molecules
Okumu, F.W. et al.: “Evaluation of the AERx Pulmonary Delivery System for Systemic Delivery of a Poorly Soluble Selective D-1 Agonist, ABT-431” Pharmaceutical Research 2002;19(7):1009-1012.

Derschwitz M. et al.: “Pharmacokinetics and Pharmacodynamics of Inhaled Versus Intravenous Morphine in Healthy Volunteers” Anesthesiology 2000;93(3):619-628.

Chan, H.K. et al.: “Deposition of Aqueous Aerosol of Technetium-99m Diethylene Triamine Penta-acetic Acid Generated and Delivered by a Novel System (AERx) in Healthy Subjects” European Journal of Nuclear Medicine 1999; 26(4): 320-37.

Mather L.E. et al.: “Pulmonary Administration of Aerosolized Fentanyl: Pharmacokinetic Analysis of Systemic Delivery” British Journal of Clinical Pharmacology 1998; 46:37-43.

Davison, S., J. Thipphawong, J. Blanchard, K. Liu, R. Morishige, I. Gonda, J. Okikawa, J. Adams, A.M. Evan, B. Otulana, and S.R. Davis. Pharmacokinetics and acute safety of inhaled testosterone in postmenopausal women. J. Clin. Pharmacol. 45: 177-184, 2005.

Peptide and Protein Delivery
Thipphawong, J. et al.: “Pulmonary Insulin Administration Using the AERx® Insulin Diabetes System” Diabetes Technology & Therapeutics 2002; 4(4): 499-504.

Sangwan, S. et al.: “Aerosolized Protein Delivery in Asthma: Gamma Camera Analysis of Regional Deposition and Perfusion” Journal of Aerosol Medicine. 2001;14(2):185-195.

Mudumba S. et al.: “Delivery of rhDNase Using the AERx® Pulmonary Delivery System” Respiratory Drug Delivery VII. Dalby R.N. et al (eds) Serentec Press, Raliegh, NC. 2000. pp. 329-332.

Brunner, G.A. et al.: “Dose-Response Relation of Liquid Aerosol Inhaled Insulin in Type I Diabetic Patients” Diabetologia 1991; 44:305-308.

Geller, D. et al.: "Bolus Inhalation of rhDNase with the AERx System in Subjects with Cystic Fibrosis" Journal of Aerosol Medicine 2003. 16(2): 175-182.

Gene Therapy
Desphande D. et al. “Aerosolization of Lipoplexes Using AERx® Pulmonary Delivery System” AAPS Pharmaceutical Sciences 2002. 4(3): 1-10.

Deshpande, D.S., J. D. Blanchard, J. Schuster, D. Fairbanks, C. Hobbs, , R. Beihn, C. Densmore, S. Farr, and I. Gonda. Gamma scintigraphic evaluation of a miniaturized AERxÒ Pulmonary Delivery System for aerosol delivery to anesthetized animals using a positive pressure ventilation system. J. Aerosol Med. 18: 34-4, 2005.

Educational Links
For more information on diabetes, access the following resources:
American Association for Drug Research
Aerosol Society
The International Society for Aerosols in Medicine
Controlled Release Society
Respiratory Drug Delivery