Tobacco smoking cessation remains arguably one of the greatest opportunities in preventive respiratory medicine. We are developing a product that delivers “clean nicotine” aerosol formulated as a solution of nicotine salt in water. We believe that if we can satisfy the initial craving for nicotine by giving patients a similar sensation from our “clean nicotine” inhalation system, then by gradual reduction of blood levels of nicotine the patients can be “weaned off” smoking.